Crystal structure of PI3Kgamma in complex with DNA-PK inhibitor AZD7648
收藏Protein Data Bank Japan2024-01-24 更新2026-03-21 收录
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Crystal structure of PI3Kgamma in complex with DNA-PK inhibitor AZD7648 Descriptor: 7-methyl-2-[(7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(oxan-4-yl)purin-8-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Authors: Schimpl, M, Goldberg, F.W, Finlay, M.R.V, Ting, A.K.T, Beattie, D, Lamont, G.M, Fallan, C, Wrigley, G.L, Howard, M.R, Williamson, B, Davies, B.R, Cadogan, E.B, Ramos-Montoya, A, Dean, E. Deposit date: 2019-10-10 Release date: 2020-01-01 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.62 Å) Cite: The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor. J.Med.Chem., 63, 2020
创建时间：
2019-10-10
