Regiospecific Syntheses of 6α-(1<i>R</i>-Hydroxyoctyl)penicillanic Acid and 6β-(1<i>R</i>-Hydroxyoctyl)penicillanic Acid as Mechanistic Probes of Class D β-Lactamases
收藏NIAID Data Ecosystem2026-03-06 收录
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The unique hydrophobic surface patches in class D β-lactamases presented an opportunity for designing two compounds, 6α-(1R-hydroxyoctyl)penicillanic acid and 6β-(1R-hydroxyoctyl)penicillanic acid, as mechanistic probes of these enzymes. In a sequence of three synthetic steps from benzhydryl 6,6-dibromopenicillanate, the targeted compounds were prepared in a stereospecific manner.
创建时间：
2016-02-26
