GWAS summary statistics for vestibular function phenotypes in the Hybrid Mouse Diversity Panel (HMDP)

Description This dataset contains genome-wide association study (GWAS) summary statistics for vestibular function phenotypes measured in the Hybrid Mouse Diversity Panel (HMDP), a collection of recombinant inbred and classical inbred mouse strains. Vestibular function was assessed using vestibular sensory evoked potentials (VsEPs) and a balance beam assay. GWAS analyses were performed using linear mixed models implemented in FaST-LMM, accounting for population structure.The dataset includes summary statistics for the following phenotypes:Young cohort (6-week-old female mice):VsEP thresholdVsEP P1–N1 amplitudeBalance beam traversal timeAged cohort (22 ± 2.5 months):VsEP threshold (male mice)VsEP threshold (female mice)Each file contains SNP-level association results derived from genotypes obtained using the Mouse Diversity Array. SNPs were filtered based on minor allele frequency (≥5%) and missingness (≤10%) prior to analysis. Association testing was performed using FaST-LMM, with a leave-one-chromosome-out (LOCO) approach for kinship matrix construction. Phenotypic values were log10-transformed prior to analysis.File contents Each GWAS summary statistics file includes the following columns (depending on availability):SNP identifier (rsID or chr:position)ChromosomeGenomic position (bp)P-valueEffect size (beta)Methods summary Mice from the HMDP were phenotyped for vestibular function using established protocols for VsEP recording and balance beam testing. GWAS was conducted using approximately 100,000–160,000 SNPs per phenotype after quality control filtering. Detailed experimental procedures and analysis methods are described in the associated manuscript.Related publication Ninoyu Y et al. “Novel Candidate Genes for Vestibular Function Identified Through GWAS in the Mouse Hybrid Diversity Panel” (BMC Genomics, under revision)