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Striatal transcriptome analysis of Shank3-overexpressing mice

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https://www.ncbi.nlm.nih.gov/sra/SRP103754
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资源简介:
Shank3 is a core excitatory postsynaptic protein enriched in the striatum. We have previously generated and characterized Shank3-overexpressing transgenic mice, and found that these mice exhibited manic-like behavioral phenotypes. To understand molecular mechanisms underlying the behavioral changes, we performed transcriptome (RNA-sequencing) analysis of the striatal tissues from 12-week-old wild-type and Shank3 transgenic mice. Overall design: Striatal transcriptome of 12-week-old wild-type and Shank3 transgenic (TG) mice.
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2017-09-17
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