Mutated genes and potential biomarkers of childhood-onset schizophrenia

We analyzed the de novo rare variants in new COS cases by Whole exome sequencing (WES) and try to find out the probable COS candidate genes. We measured the rate of de novo variants (DNVs) and used WGCNA to construct a network of coexpressed genes, we also checed differential DNA methylation between COS Disease groups, COS Dangerous groups, and Normal groups.