Effects of lactoferrin on serum mediators in HFCS-induced murine HMMS.

Following eight weeks of lactoferrin administration (0, 50, 100, and 200 mg/kg), levels of serum LPS (sLPS), serum ALT (sALT), serum triglyceride (sTG), serum cholesterol (sCHOL), and serum bovine lactoferrin (sbLf) were significantly higher in the control group than in the naïve group (P<0.05). sLPS, sALT, sTG, and sCHOL were significantly lower in the lactoferrin-treated groups than in the control group (P<0.05). sbLf was significantly higher in the lactoferrin-treated groups than in the control group, in a dose-dependent manner. Data are presented as the mean ± SD (n = 10), and were analyzed using one-way ANOVAs and Duncan's multiple range test. a–d: Different letters in the same row indicate a significant difference (P<0.05).