microRNAs are small non-coding RNAs that can affect gene expression. We used microarrays to analyze gene expression in miR-499 transgenic mouse hearts. Overall design: Cardiac ventricles were collecte

NIAID Data Ecosystem60

SOX9 manipulation in human melanoma cell culture [RNA-seq]

黑色素瘤分子机制

基因表达谱分析

RNA-seq profiling to compare gene expression in non-transfected A375 cells and A375 cells transfected with SOX9-HA. RNA-seq from 3 external replicates of non-transfected vs. 5µg SOX9-HA transfected A3

NIAID Data Ecosystem50

Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-?B Pathway in Melanoma

黑色素瘤分子机制

NF-κB通路调控

Melanoma is a highly aggressive cancer with increasing incidence rates and a poor survival, particularly in patients with AJCC stage IV and advanced stage III. Deregulation of NF-kB is linked to diffe

NIAID Data Ecosystem70

Importance of RAD6B in activation of canonical WNT signaling in melanoma development

黑色素瘤分子机制

Wnt信号通路调控

We have demonstrated that RAD6B, a ubiquitin conjugating enzyme that is a principal component of translesion synthesis pathway, stabilizes and transcriptionally activates beta-catenin by lysine 63-lin

NIAID Data Ecosystem60

miR-193b represses cell proliferation and regulates cyclin D1 in melanoma

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