Impact of an integrated intervention package during preconception, pregnancy, and early childhood on inflammation, IGF-1, IGFBP3 during the first 6 months of life: Findings from the WINGS randomized controlled trial

Early-life interventions targeting maternal and child health, nutrition, and psychosocial care may influence infant growth and immune development by modulating systemic inflammation and growth factor pathways. However, causal evidence of comprehensive, integrated interventions initiated during early life is limited. The study was nested in a factorial randomized controlled trial (RCT) in women aged 18–30 years. Participants included in this study were randomized to receive either a preconception intervention package or routine care until early childhood.  The intervention included health care for growth-related conditions, nutrition, WASH (water, sanitation, and hygiene), and psychosocial care. The primary study demonstrated a substantial effect of the intervention on growth and development. Blood samples from 381 (178 from the intervention group and 203 from the control group) infants were analyzed at 3 and 6 months of age for inflammatory and growth-related biomarkers: C-rea..., , # Impact of an integrated intervention package during preconception, pregnancy, and early childhood on inflammation, IGF-1, IGFBP3 during the first 6 months of life: Findings from the WINGS randomized controlled trial

Dataset DOI: [10.5061/dryad.6t1g1jxbs](https://doi.org/10.5061/dryad.6t1g1jxbs)

## Description of the data and file structure

File: dataset_inflammatorymarkermanuscript_28.11.25.xlsx

Integrated Intervention Effects on Infant Inflammation and IGF Axis

The dataset originated from a randomized controlled trial. The study involved recruitment, interventions, and follow-up assessments. Blood samples were collected by the research team. All outcome assessments were conducted by a separate team that was not involved in the intervention delivery and was blinded to group assignments before the measurement process. Ethical clearance for this study was granted by the Ethics Review Committee of the Society for Applied Studies, New Delhi, India. This study was registered with the ..., I confirm that I received informed consent from the participants to publish the de-identified data in the public domain, and I have removed all the personal identifiers from the data.