Data from: Synthesis of gypsogenin derivatives with capabilities to arrest cell cycle and induce apoptosis in human cancer cells

Thirty-two gypsogenin derivatives were synthesized and screened for their
cytotoxic activities. Their structures were established using IR, 1H NMR,
13C NMR, and LC-MS spectroscopic data. In MTT assays nearly all the
compounds displayed good cytotoxicity in the low μM range for several
human tumour cell lines (A549, LOVO, SKOV3 and HepG2). Low IC50 values
were obtained especially for the carboxamides 7a–7j, for an oxime
derivative 3 and a (2,4-dinitrophenyl)hydrazono derivative 4. In
particular, the IC50 values of compounds 4 (IC50 = 2.97 ± 1.13 µΜ) and 7 g
(IC50 = 3.59 ± 2.04 µΜ) against LOVO cells were found to be much lower
than those of the other derivatives and parent compound. These compounds
were submitted to an extensive biological testing and proved compounds 4
and 7 g to act mainly by an arrest of the tumour cells in the S phase of
the cell cycle. In addition, compounds 4 and 7 g triggered the apoptotic
pathway in cancer cells, showing high apoptosis ratios.