Off-target events in PD1-19bbz cells detected by WGS
收藏NIAID Data Ecosystem2026-03-13 收录
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资源简介：
We successfully develop a two-in-one approach to generate non-viral genome specific targeted CAR T cells through CRISPR/Cas9. In the adoptive therapy for relapsed/refractory aggressive B-cell non-Hodgkin lymphoma, we observed durable responses without serious adverse events and complete remission in patients treated with these PD1 knockout CAR T cells. Here we applied WGS to detect off-target events in PD1-19bbz cells.
创建时间：
2022-09-09
