One-pot Multicomponent Synthesis of N2,6-Substituted 1,3,5-triazine-2,4-diamines as Potential Antileukemic Agents

A new practical method for synthesizing 4-aryl-6-cycloamino-1,3,5-triazine-2-amines and bis(1,3,5-triazine-2,4-diamines) was developed. This method is suitable for generating combinatorial libraries of potentially bioactive compounds. Initially, 94 compounds with the 4-aryl-6-cycloamino-1,3,5-triazine-2-amine scaffold were prepared and screened for their antileukemic activity using Jurkat T-cell lines. This method was then successfully extended to the synthesis of bis(1,3,5-triazine-2,4-diamines).