[BMim]OH Functionalized Ionic Liquid-Mediated Construction of Ferrocenyl β‑Ketosulfone Derivatives

The first 1-butyl-3-methylimidazole hydroxide ([BMim]OH)
functionalized
ionic liquid-mediated catalytic strategy was proposed for the construction
of ferrocenyl β-ketosulfone derivatives. A series of novel ferrocenyl
derivatives were synthesized by a facile one-step reaction of chloroacetylferrocene
with sodium sulfinates in dichloromethane (DCM) under air and mild
conditions. All these synthesized ferrocenyl derivatives were comprehensively
characterized using NMR (1H and 13C) spectroscopy
as well as HRMS techniques. Compounds 3a, 3d, and 3f were further confirmed using single crystal
X-ray diffraction analysis. This catalytic approach provided a straightforward
and effective synthetic strategy for the assembly of structurally
diverse ferrocenyl β-ketosulfones with high step-economy and
exceptional functional group tolerance. The results could facilitate
the functionalized application of developing new ferrocenyl β-ketosulfone
derivatives.