Comparison of the main attributes of protein-protein interaction networks (interactomes) of unstressed and heat shocked yeast cells.

aWe used median values, since distributions were not considered normal distributions. The average values of distributions showed similar results (data not shown).bWeighted diameters were calculated by the igraph library as a Python extension module (version 0.5.4, http://igraph.sourceforge.net/) using Dijkstra's algoritm [27].cDegree denotes the effective degree of a yeast interactome node, which was calculated as the effective number of weighted interactions of the respective node (see Materials and Methods for more details).dA hub was defined as a node having more than 92 effective weighted degree (this was the effective weighted degree threshold of the top 1% of nodes having a maximal effective weighted degree in the interactome of non-stressed yeast cells).