Selective IgM digestion improves anti-AAV IgG detection in the immune complex assay format
收藏Taylor & Francis Group2025-09-05 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/Selective_IgM_digestion_improves_anti-AAV_IgG_detection_in_the_immune_complex_assay_format/30042099/1
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资源简介：
To confirm the observation of IgM interference in the anti–adeno-associated virus (AAV) IgG immune complex (IC) assay format and to verify that IgM-specific digestion can improve anti-AAV IgG detection in IC assays. Treatment-emergent anti-AAV2 and anti-AAV9 IgG signals were measured in IC assays with and without IgM-specific digestion. Anti-AAV2 and anti-AAV9 IgM signals were measured in parallel. IgM digestion increased anti-AAV2 and anti-AAV9 IgG signals when anti-AAV2 or anti-AAV9 IgM were present in the matrix. Co-existing anti-AAV IgM cause interference in the anti-AAV IC assay format. Selective IgM digestion improves the detection of anti-AAV IgG in the IC assay.
提供机构：
Pöhler, Alexander; Stubenrauch, Kay-Gunnar; Ros, Francesca; Wessels, Uwe
创建时间：
2025-09-03
