DYRK2 stabilization has dual effects on apoptosis and self-renewal of leukemia stem cells that can be targeted in chronic myeloid leukemia. Mus

Gene expression analysis of leukemic stem cells (LSC) from WT and KLF4-deficient BCR-ABL p210-induced chronic myeloid leukemia (CML) mice Loss of Klf4 impairs self-renewal and survival of LSC in CML. Analysis provides insight into function of KLF4 in leukemia. Overall design: BCR-ABL p210+ lineage- Sca-1+ c-Kit+ (GFP+ LSK) cells were sorted from WT and Klf4 deficient CML mice induced by BCR-ABL p210 at 14 days after transplantation. Sorted cells were subjected to gene expression analysis.