Association between ICA gene expression patterns (G), smoking (S) and plaques (P).

n: number of genes in the pattern-specific module, b: sign of the regression coefficient of G on S and G on P, respectively. All models included age, sex and the first 6 SVD components. Only the 29 patterns that passed quality control are shown. P-values ≤0.05/29 = 0.0017 are in bold. Genes are ranked by increasing r2D associated to S in the model P∼S|G, which corresponds to decreasing reduction of the amount of covariation between smoking and plaques explained by pattern expression.