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Evidence for CD04+ T Cell Methylation Signatures of Network-oriented SOCS3, ITGAL, and NR4A2 Genes with Hemodynamics in Patients with Pulmonary Arterial Hypertension (Array1 DataSet)

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE165356
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We hypothesized that methylation dynamics in circulating CD04+ T cells may underlie a precise transcriptional reprogramming that associates with the cardiopulmonary hemodynamic profile of affected patients. We aimed at profiling DNA methylome of circulating CD04+ T cells from patients with PAH and controls by integrating network medicine and hemodynamic parameters. Identification of differentially methylated CpGsites (dmCpGs) annotated to specific genes able to discriminate circulating CD04+ T cells isolated from PAH and controls.
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2023-03-09
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