FOSL1 modulates Schwann cell responses in the wound microenvironment and regulates peripheral nerve regeneration

Peripheral glial Schwann cells switch to a repair state after nerve injury, proliferate to supply lost cell population, migrate to form regeneration tracks, and generates a permissive microenvironment for nerve regeneration. Exploring essential regulators of the repair responses of Schwann cells may benefit the clinical treatment for peripheral nerve injury. In the present study, FOSL1 regulates Schwann cell phenotype modulation and provided a novel therapeutic approach to orchestrate the regeneration and functional recovery of injured peripheral nerves. ChIP-seq was used to identify FOSL1-FLAG-target protein binding target genes in primary Schwann cells of rat newborn sciatic nerve