Stimulation with M.tb peptide pool induces multiple signaling pathways involved in providing protection during M.tb infection

M.tb Peptide pool induces an intricate network of signaling pathways in DCs and T cells which leads to enhanced cytokine production and T cell activation. Overall design: To understand the host changes at the transcription levels leading to an increased T cell activation and an augmented pro-inflammatory cytokine upon M.tb peptide pool treatment, we performed comparative transcriptome analysis of unstimulated dendritic cells DCs (Un-DC) vs peptide pool pulsed DCs (Pep-DC) and T cells co-cultured with unstimulated DCs (Un-TC) vs T cells co-cultured with peptide pool pulsed DCs (Pep-TC).