Comparison of FDRs (top line) and P-values (in brackets) for Central Europe-Toronto (CETO) and Germany-MD Anderson (GRMD) for top lung cancer risk associated pathways identified by different analysis methods using GO level 4 pathways.

Bold: significant after adjustment for multiple comparisons (FDR≤0.05) in both CETO and GRMD.
Bold with italics: significant after adjustment for multiple comparisons in one data set (FDR≤0.05), nominal significance in other (P≤0.05).
Underline: Top pathways identified by more than one pathway analysis method within a data set.
†Abbreviated GO category name. Full category names as follows: Ras-GEF: Ras guanyl-nucleotide exchange factor; LDL binding: low-density lipoprotein binding; acetylcholine receptor: acetylcholine receptor activity; immune response: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; complement activation: complement activation, classical pathway; somatic recombination: somatic recombination of immunoglobulin gene segments; peptide receptor: G-protein coupled peptide receptor activity; positive reg phosphorous: positive regulation of phosphorus metabolic process; antigen processing: antigen processing and presentation of peptide antigen via MHC Class I; retrograde transport, GER: Retrograde vesicle mediated transport, golgi to endoplasmic reticulum.
‡Significant based on Benjamini-Hochberg FDR calculation.