Genome-wide analysis of ETS factor ER71/ETV2 chromatin occupancy
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
We discover that ER71/ETV2 initiates hemangiogenic program by activating blood and endothelial cell lineage specifying genes while enhancing FLK1 expression and expanding hemangioblast population. Furthermore, ER71/ETV2 establishes an ETS hierarchy by directly activating Ets genes in hematopoietic and endothelial cell lineage development. As such, ER71/ETV2-initiated blood and endothelial cell program is maintained by ER71/ETV2 downstream ETS factors through an ETS switching mechanism.
提供机构：
Washington University in St. Louis
创建时间：
2022-02-20
