Neuro-condition media of mesenchymal stem cells (MSCs) inhibited the proliferation and pluripotency of glioma stem cells,

We used microarray global gene expression profiling to investigate the effect caused by neuro-condition media of MSCs on the growth and pluripotency of glioma stem cells. The effect was specifically investigated for cell cycle arrest, cell differentiation, invasion and self renewal ability of glioma stem cells, Paracrine factors from six biological samples of MSCs( 3 WJ-MSCs, 3 BM-MSCs) were collected as treatment and were applied on actively growing glioma stem cells as spheroids for 7 days.