Enantioselective Imidazole-Directed Allylation of Aldimines and Ketimines

A new chiral allylchlorosilane has been developed that allows the highly enantioselective allylation and crotylation of a range of
2-imidazolylaldimines and ketimines. The method may be exploited for the protecting group-free synthesis of a diverse array of imidazole-bearing chiral carbinamines and, when coupled with ring-closing metathesis reactions, allows the one-pot synthesis of unusual heterocyclic
motifs with potential relevance in medicinal chemistry.