SPL7013 and SPL7115 have broad-spectrum activity against HIV-1 strains and HIV-2 as determined in TZM-bl cells.

aX4 denotes HIV that uses the CXCR4 chemokine receptor for entry, R5 denotes HIV that uses the CCR5 chemokine receptor for entry and dual tropic use both X4 and R5 receptors for entry.
b50% effective concentration (EC50) was determined in the TZM-bl indicator cell line from at least three independent assays.
cLate CCR5 HIV-1 virus isolated from PBMC of individuals with AIDS (CDC category IV disease) and CD4 counts <50 cells/µl.
fNB25 and NB27 are early CCR5 HIV-1 isolated from PBMC of individuals that was asymptomatic with CD4 counts >500 cells/µl (CDC category II disease) or was an acute seroconvertor with CD4 counts >750 cells/µl (CDC category I disease), respectively [17].