Single-nucleus atlas of camel liver development and comparison with cattle reveals adaptive metabolic functions
收藏科学数据银行2025-12-17 更新2026-04-23 收录
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资源简介：
Camels adapt to the harsh conditions by storing fat, which highlights the need to understand their liver adaptations. This study uses single-nucleus RNA sequencing to create a developmental atlas of the Bactrian camel (Camelus bactrianus) liver across newborn, weaning, and adult stages, analyzing 57,036 cells and identifying 19 cell types, including hepatocytes, liver sinusoidal endothelial cells (LSECs), and immune cells. We identified a special LSEC subtype, not seen in cattle or humans, with high hepatocyte growth factor activator (HGFAC) expression that activates hepatocyte growth factor (HGF). Hepatocyte pseudotime trajectories show a shift from proliferative to metabolically mature states, with fatty acid metabolism gene expression matching changes in milk composition. Immune cell composition shifts from Kupffer cell dominance in newborns to T cell dominance in adults, with high conservation between adult camels and cattle. These results reveal liver biochemical adaptations that support camel resilience to arid conditions, providing insights for human liver studies and livestock breeding in harsh agricultural settings.
提供机构：
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China
创建时间：
2025-12-17
