Data from: Effects of Lewy body disease and Alzheimer’s disease on brain atrophy and cognitive dysfunction

Objectives: We investigated the independent and interaction effects of
Alzheimer’s disease (AD) and Lewy body disease (LBD) on cognition and
brain atrophy. Methods: We consecutively recruited 38 controls and 108
patients with AD-related cognitive impairment (ADCI) and/or LBD-related
cognitive impairment (LBCI) from university-based dementia and movement
clinics. Diagnoses of ADCI and LBCI were supported by 18F-Florbetaben PET
and 18F-FP-CIT-PET, respectively. There were 38 controls, 26 patients with
pure ADCI (18 mild cognitive impairment (MCI) and 8 dementia), 28 patients
with pure LBCI (13 MCI and 15 dementia), and 54 patients with mixed ADCI
and LBCI (17 MCI and 37 dementia). We performed group-wise comparisons for
neuropsychological z scores and regional cortical thickness. We also
evaluated the effects of ADCI and LBCI using general linear models.
Results: Compared to the controls, pure patients with ADCI group and pure
LBCI group had focused cortical thinning in the bilateral entorhinal/right
anterior temporal cortices and bilateral anteromedial temporal/basal
frontal cortices, respectively, while the mixed disease group had
additional cortical thinning in the widespread association cortices. The
independent effects of ADCI and LBCI on regional cortical thinning
overlapped in the widespread association cortices, especially at the
bilateral temporo-parietal junction and parietal cortices. ADCI and LBCI
had independent detrimental effects on the copying item of the
Rey-Osterrieth Complex Figure Test. Conclusions: Concomitant ADCI and LBCI
are associated with the accentuation of neurodegeneration to widespread
association cortices, and both diseases contribute to visuospatial
dysfunction.