Lionheart LincRNA Alleviates Cardiac Systolic Dysfunction under Pressure Overload

to screen upregulated lincRNAs in pressure overloaded hearts, we conducted microarray analysis To identify transcribed intergenic regions that yield upregulated lincRNAs during cardiac remodeling, we performed a screen using total RNA extracted from mouse hearts subjected to transverse aortic constriction (TAC) surgery. In this screen, we assessed two time points at 2 weeks and 8 weeks after TAC surgery for the hypertrophic response and the heart failure phase, respectively.