Extracellular vesicles derived from ASCs Deliver Mitochondria Reprogramming DCs Metabolism to Alleviate Rat TMJOA

EVs contain mitochondria that are transferred to condylar DCs. This action triggers ERK1/2/FoxO1/ autophagy pathway internalization of phagocytosed mitochondria by mitochondrial recipient cells, which subsequently affect fatty acid metabolism in DCs to metabolically reprogram them. Thus, DCs changed from an activation state to a tolerance state. Taken together, our findings suggested that EVs reprogram the states of condylar DCs by transferring functional mitochondria into them and affecting their fatty acid metabolism, which highlights the therapeutic value of EVs for TMJOA. Overall design: To explore the mechanism by which EVs exert their effects, we subjected DCs with different treatments to RNA sequencing