EEG Recordings for: Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures

Engagement of the basal ganglia experimental seizures was first observed
almost 75 years ago. However, the role of the basal ganglia’s input
nucleus, the striatum, in seizure control is relatively understudied. To
address this gap, we used an optogenetic approach to activate and
inactivate neurons in the dorsal striatum of rats submitted to the
gamma-butyrolactone (GBL) model of absence epilepsy, amygdala kindling
model of temporal lobe epilepsy, and pilocarpine-induced Status
Epilepticus (SE).  Open-loop (continuous light delivery)
optogenetic activation of  dorsal striatal neurons robustly
suppressed seizures in all models. By contrast, open-loop optogenetic
silencing increased absence seizure expression and facilitated SE onset
but had no effect on kindled seizures. In the GBL model, we also tested
the effects of closed-loop modulation (light delivery in response to
seizure detection). Closed-loop activation reduced duration of spike-wave
discharges (SWDs), while closed-loop inhibition increased SWD duration.
This dataset includes electroencephalographic recordings for each subject
and test session in the manuscript are included as european data format
(.edf) files.  These results demonstrated previously unrecognized
anti-absence effects associated with striatal neuromodulation. These
findings demonstrate a robust, bidirectional role of the dorsal striatum
in the control of multiple seizure types, suggesting that the striatum is
a site that can exert broad-spectrum control of seizures.