A novel DNA methylation disruption contributes to ALKi resistance in NSCLC
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78217
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资源简介：
Acquired resistance to ALKi in NSCLC patients is attributed to gain of mutations in the ALK-EML4 fusion gene and an enhancement of the EGFR and/or IGF1R pathways. Here, we explain the epigenetic change that drives the EGFR and IGF1R reactivation in the absence of the appearance of an ALK-EML4 mutated scenario. The NSCLC cell line H3122 (positive for ALK-EML4 translocation) was used for deriving resistant clones to ALK inhibitors TAE684 and crizotinib.
创建时间：
2021-02-02
