Power calculations.

Cohort: study used for eQTL data, Tissue: eQTL summary statistics obtained from this tissue, n eQTL: sample size for eQTL specific to tissue, r2 eQTL: proportion of variance in exposure variable explained by SNPs in gene expression GWAS, Outcome: trait used as outcome for MR, Outcome category: trait category, βOLS: regression coefficient for the observational association between the exposure and continuous outcome variables, βyx: unknown true causal association between exposure and continuous outcome, σ2 eQTL: variance of the exposure variable, σ2 GWAS: variance of the continuous outcome variable, n GWAS: sample size of GWAS, n cases GWAS: sample size of cases for binary outcomes, True OR: true odds ratio of the outcome variable per standard deviation of the exposure variable, K: proportion of cases in binary outcome, Power: estimated power for the exposure-outcome combination. (XLSX)