Effects of Huatan Jiangzhuo Decoction and Poria cocos - Alismatis Rhizoma on gene expression in liver of rats with hyprelipidemia

Huatan Jiangzhuo Decoction, a traditional Chinese medicine composition, has been used to treat patients with hyperlipidemia (HLP). To investigate the therapeutic mechanism of Huatan Jiangzhuo decoction(HTJZD) and Poria cocos (PC) - Alismatis Rhizoma (AR) on gene expression in liver of rats with HLP, this study performed gene expression profiling analysis using data obtained from RNA-seq technology. It’s predicted that the potential role of regulating the expression of differentially expressed genes in the treatment of HLP by HTJZD and PC-AR separately. Firstly, the rat model of HLP was established by the fed with high-fat diet (HFD). Next, In the intervention phase, the rats in control group were fed with normal diet and the rat model were continuously supplied with HFD but regrouped into three groups: model group, HTJZD group and PC-AR group. Liver samples of rats which was used in RNA-seq to explore the underlying mechanism of effects of HTJZD and PC-AR in HLP. 4 experimental conditions, 1 time point