Probabilities of source aberration with downstream target for breast cancer subtypes.

For PAM50 subtypes of breast cancer, the heatmap represents the probabilities that the indicated gene is a DNA-aberrant source gene with some downstream RNA-aberrant target. The sources are selected from the set of core genes for coverings of the given tissue; the selection criterion is that the probability of a DNA-aberration is high for at least one of the subtypes for that tissue. Core sources with varying probabilities present interesting candidates for discrimination between subtypes. For example, the DNA-aberration frequency of TP53 is much higher in the HER2-enriched and Basal-like subtypes than in Luminal A and Luminal B, whereas an aberration in PIK3CA is less frequent among basal-like samples than among the other subtypes.