Replication Data for The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice
收藏NIAID Data Ecosystem2026-05-02 收录
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https://doi.org/10.7910/DVN/TAEUOA
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资源简介：
Recently, we generated Cyp2c70-/- mice with a human-like BA composition lacking mouse/rat specific muricholic acids. We employed this model to assess the consequences of a human-like BA pool on atherosclerosis and heart function in hypercholesterolaemic mice. We overexpressed a PCSK9 gain-of-function (GOF) mutation in the liver of male Cyp2c70-/- and Cyp2c70+/- control mice, and fed these mice a Western-type diet (WD) for 12 weeks.
创建时间：
2025-01-10
