The microRNA landscape of MYCN-amplified neuroblastoma. The microRNA landscape of MYCN-amplified neuroblastoma

Neuroblastoma is a common childhood cancer with almost a third of those affected still dying, thus new therapeutic strategies need to be explored. Current experimental therapies focus mostly on inhibiting oncogenic transcription factor signalling. Dysregulation of miRNAs has oncogenic or suppressive tumor functions in a variety of cancer, also including neuroblastoma. Therefore, we investigated the miRNA landscape in 97 neuroblastoma samples from different INSS stages, including MYCN-amplified (MNA) tumor samples. Overall design: Small RNA-sequencing (miRNA) of neuroblastoma samples.