Frequency of the different DRB1*03:01-containing haplotypes in multiple sclerosis (MS) patients stratified by the presence/abscence of oligoclonal IgM against myelin lipids (M+/M−) and in controls; and comparisons between groups.

% are referred to the total number of haplotypes analysed in each group (last row).AH 18.2 includes haplotypes carrying DRB1*03:01, DQB1*02:01, TNF -376A, TNF a1b5 and B*18. AH 8.1 includes haplotypes carrying DRB1*03:01, DQB1*02:01, TNF -308A, TNF a2b3 and B*8. Haplotypes with all the remaining allelic combinations in those loci or markers are included as “non-conserved” haplotypes.HLA-DRB1*15:01-containing haplotypes in MS patients were removed from the analysis.