Visible-Light-Promoted Radical C–H Trifluoromethylation of Free Anilines

The trifluoromethyl-substituted
anilines are biologically active
compounds and useful building blocks. In this communication, we have
developed the first visible-light-induced radical tri­fluoro­methyla­tion
of free anilines with the commercially available and easily handled
Togni reagent at room temperature. The resulting products were successfully
transformed into a variety of valuable fluorine-containing molecules
and heterocyclic compounds. This protocol provides an economical and
powerful route to trifluoromethylated free anilines.