An ancestral Wnt-Brachyury feedback loop and vertebrate-specific recruitment of mesoderm-determining target genes revealed by comparative Brachyury target screens

Transcription factor brachyury plays a key role during mesoderm development in vertebrates. In this study we study study the effect of this transcription factor in diploblastic cnidarian model organism N. vectensis Overall design: Brachyury binding sites were identified with ChIP-seq and effect of brachyury binding on gene expression was studied with RNA-seq