Replication Data for: B.M. Crosland, M.R. Johnson, and E.A. Matida (2009) Characterization of the Spray Velocities from a Pressurized Metered-Dose Inhaler, Journal of Aerosol Medicine and Pulmonary Drug Delivery, 22(2):85-97 (doi: 10.1089/jamp.2008.0687).

We have made detailed, spatially-resolved velocity measurements of the spray emitted from salbutamol sulfate pMDIs (pressurized metered dose inhalers) using particle image velocimetry (PIV). Instantaneous planar velocity measurements were taken and ensemble-averaged at various times during the spray event. The mean spray velocities were shown to be bimodal in time with two velocity peaks. Planar velocity data were analyzed to produce prescriptive velocity profiles suitable for use in numerical simulations. Statistical comparisons from several thousand spray events indicate that there is no significant difference in measured velocity between i) two brands of pMDI canisters, ii) two similar pMDIs from different lots, and iii) a full pMDI versus an almost-empty pMDI. Further experiments with a secondary air flow of 30 SLPM with and without an added cylindrical spacer deflected the spray downward, but had little effect on the velocity magnitude. The .xlsx file contains a summary of these results. Various worksheets contain the measured velocities, root-mean-squared variation of velocity, and curve-fit equations for the velocity in the x and y directions. All data are reported 1 mm downstream of the pMDI mouthpiece in a plane parallel to the exit plane.