Development and characterization of two canine melanoma cell lines with distinct clinical profiles: new models for comparative oncology

In order to develop a new canine model of melnoma, we isolated and characterised three cell lines from oral canine malignant melanoma samples obtained from patients presenting distinct clinical behavior Total DNA was extracted from tumor tissues, the isolated cell lines and respective blood samples of each patient for the control. Our results highlight genomic melanoma alterations in accordance with the published litterature (Poorman et al, 2015; Gillard et al, 2014) and profiles reflecting the aggressivness and clinical evolution of each tumor.