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Epigenetically programmed ‘stem-like’ tissue resident memory CAR T-cells exhibit robust activity against solid and liquid tumors

NIAID Data Ecosystem2026-03-14 收录

CAR-T细胞疗法

肿瘤免疫治疗

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE224866 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-03-08

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铁代谢与肿瘤微环境

Iron is both, an essential compound for many metabolic processes, and iron deficiency can impact on the proliferation of cells including lymphocytes but also tumor cells. On the other hand, excess iro

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20191204_EGA_MELA_Rizos - samples

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RNA测序分析

79 RNAseq samples from 56 patients with melanoma who have undergone immune checkpoint blockade immunotherapy.EGA dataset EGAD00001005738

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Table S1 from Intratumoral Plasmid IL12 Expands CD8 + T Cells and Induces a CXCR3 Gene Signature in Triple-negative Breast Tumors that Sensitizes Patients to Anti–PD-1 Therapy

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癌症生物标志物

Table S1

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Table_3_Deep dive into the immune response against murine mesothelioma permits design of novel anti-mesothelioma therapeutics.xlsx

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临床评估

Given the need to improve the efficacy of standard-of-care immunotherapy (anti-CTLA-4 + anti-PD-1) in human malignant pleural mesothelioma (hMPM), we thoroughly characterized the immunobiology of the

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Interleukin-10/CSF1R fusion protein rejuvenates the exhausted T cells for executing antitumor activity III

肿瘤免疫治疗

RNA测序分析

Bulk RNA sequence (RNA-seq) has been used to explore the effect of IL10/CSF1R fusion protein modulation in tumor microenvironment. Four groups were analyzed which contain Ctrl, CSF1R, IL10 and BF10.

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Epigenetically programmed ‘stem-like’ tissue resident memory CAR T-cells exhibit robust activity against solid and liquid tumors

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