IRE-1 is required for lifespan extension by <i>hif-1</i>.

The lifespan experiments were performed for twice with consistent results. Data for representative experiments are shown in this table, and data for repeated experiments are shown in Table S5. aaverage lifespan±standard deviation in days. bchanges in mean lifespan compared to N2 growing at the same food concentration. cnumbers of animals scored. dp-values were calculated for log-rank tests by comparison to N2 growing at the same food concentration. elog-rank test: ire-1 AL vs. ire-1; hif-1 AL, p = 0.9076. flog-rank test: ire-1 DR vs. ire-1; hif-1 DR, p = 0.5445.