Crystal structure of Bcl-2 in complex with prodrug ABBV-167
收藏Protein Data Bank Japan2023-10-18 更新2026-03-21 收录
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Crystal structure of Bcl-2 in complex with prodrug ABBV-167 Descriptor: Apoptosis regulator Bcl-2, Phosphoric acid mono-[5-(5-{4-[2-(4-chloro-phenyl)-4,4-dimethyl-cyclohex-1-enylmethyl]-piperazin-1-yl}-2-{3-nitro-4-[(tetrahydro-pyran-4-ylmethyl)-amino]-benzenesulfonylaminocarbonyl}-phenoxy)-pyrrolo[2,3-b]pyridin-7-ylmethyl] ester Authors: Judge, R.A, Salem, A.H. Deposit date: 2021-01-21 Release date: 2021-04-14 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.068 Å) Cite: Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol.Cancer Ther., 20, 2021
创建时间：
2021-01-21
