Data SD1 from Probabilistic Mixture Models Improve Calibration of Panel-derived Tumor Mutational Burden in the Context of both Tumor-normal and Tumor-only Sequencing

The panel inputs in Data S1 contain all variants which fell within the coordinates of the respective panels and coverage WIGs and CDS and divided by the covered panel CDS size in Mb. As a result these counts include synonymous mutations as well as hotspots. Because germline data is potentially sensitive information we anonymized the sample names. Samples which had less than 400 germline counts in the 4 Mb region prior to filtering were excluded from the germline inputs.