Distribution of single-nucleotide polymorphisms (SNPs) and deletion-insertion polymorphism (DIPs) that caused an amino acid change and had a frequency above 80% in the peptidomimetic-adapted genome-sequenced isolates.

a1isolates with high levels of resistance i.e. 8–16×wild type MIC, 2 isolates with intermediate levels of resistance i.e. 4–8×wt MIC; 3 Isolates with wild type MIC.bTwo SNPs were present in the macB gene: one SNP causing amino acid 319 in the protein to change from Asp to Tyr (X) and one causing amino acid 505 to change from Trp to Leu (x).cTwo SNPs were present in the macA gene: one SNPs causing amino acid 91 in the protein to change from Val to Gly (X) and one causing amino acid 205 to change from Val to Leu (x).dDIP mutations; all other mutations are SNPs.