Plasma proteomics of Ghanian children from high malaria transmission (HMT) and low malaria transmission (LMT) zones

We performed a longitudinal study of the plasma proteome of children infected with malaria and residing in low or high malaria transmission areas in Ghana. A mass spectrometry-based approach was used to identify putative protein-based biomarkers and predictors of resistance to malaria. Our findings confirm earlier reports and identify putative signature proteins implicated in immune tolerance to malaria.