MUCOSAL EXPRESSION OF GENES PI3, ANXA1, AND VDR DESCRIMINATES CROHN’S DISEASE FROM ULCERATIVE COLITIS IN INFLAMMATORY BOWEL DISEASE PATIENTS

Differential diagnosis in inflammatory bowel disease (IBD) patients from the start of the diagnosis is challenging. In this study we tried to discriminate two subtypes of IBD such as Chron's disease(CD) and Ulcerative colitis (UC) using differential expression of genes from formalin-fixed paraffin-embedded mucosal biopsies of 33 IBD patients and 10 healthy controls. Whole transcriptome RNA sequencing was performed using AmpliSeq human gene expression panel on FFPE colonic mucosal biopsies of IBD patients (CD, n=16, UC, n=17) and non-IBD controls (n=10) to study differential gene expression between CD and UC samples. NOTE FROM SUBMITTER: Raw data generated during the current study can not be made publicily available, which is in accordance with the rules concerning processing of personal data set out in the EU General Data Protection Regulation (GDPR) and the Danish Data Protection Act. Nonetheless, may a researcher have an interest in our data they are welcome to contact us and collaborate. The data that support the findings of this study can be requested from The National Secretariat for Bio- and Genome Bank Denmark, [e-mail], Herlev Hospital, Borgmester Ib Juuls Vej 73, 2730 Herlev, Denmark.