pAUROCs using different methods to rank the DDIs.

In set 1, interactions well-established, probable and theoretical are considered true positives (TP). In set 2, interactions well-established and probable are considered TP. In set 3, only interactions well-established are considered TP. Set 4 included interactions with high and moderate clinical significance as TP. Set 5 included only highly clinically significant interactions as TP. Drugdex (sets 1–3) and Drugs.com (sets 4–5) were used as reference standards.