STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

NIAID Data Ecosystem2026-03-13 收录

线粒体融合机制

STAT6蛋白功能

数据链接：

https://data.mendeley.com/datasets/44fxxng896 数据链接链接失效反馈

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资源简介：

All raw data including original immunoblot, confocal images, and statistics have been deposited.

创建时间：

2022-08-08

Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [PDX shOPA1]. Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [PDX shOPA1]

急性髓系白血病治疗

线粒体融合机制

Mitochondrial metabolism recently emerged as a critical dependency in acute myeloid leukemia (AML). The shape of mitochondria is tightly regulated by dynamin GTPase proteins, which drive opposing fusi

NIAID Data Ecosystem70

Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [PDX shMFN2]. Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [PDX shMFN2]

急性髓系白血病治疗

线粒体融合机制

NIAID Data Ecosystem40

GO:0008053 (mitochondrial fusion)

线粒体融合机制

基因-蛋白质相互作用

This network was assembled automatically by INDRA (http://indra.bio) by processing all available biomedical literature with multiple machine reading systems, and integrating curated pathway databases.

NIAID Data Ecosystem20

Nucleotide-free Mitofusin2 (MFN2)

线粒体融合机制

蛋白质结构解析

Nucleotide-free Mitofusin2 (MFN2) Descriptor: CALCIUM ION, GLYCEROL, Mitofusin-2,cDNA FLJ57997, ... Authors: Li, Y.J, Cao, Y.L, Feng, J.X, Qi, Y.B, Meng, S.X, Yang, J.F, Zhong, Y.T, Kang, S.S, Chen, X

Protein Data Bank Japan2023-11-22 更新60

Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia [Cell lines shCTL shMFN2]

急性髓系白血病

线粒体融合机制

NIAID Data Ecosystem40