IL6 gene produces IL6 protein

The gene for IL-6 is located at chromosome 7 whose unit transcription consists of 5 exons and 4 introns. The promoter region contains several transcription start sites with response elements for nuclear factor (NF)-κB, enhancer-binding protein beta (C/EPBβ; formerly NF-IL6), activator protein (AP)-1 (Burger 2013) and CREB transcription factor (Dendorfer et al. 1994). The protein form of human IL-6 is a glycoprotein composed of 184 amino acids with a molecular weight of 21-28 kDa, depending on its degree of glycosylation. It has a 4-helix bundle structure made up of 4 long α-helices arranged in an up-up-down-down topology (Burger 2013).

IL-6 基因定位于第7号染色体，其单位转录由5个外显子和4个内含子组成。启动子区域包含多个转录起始位点，以及针对核因子（NF）-κB、增强子结合蛋白β（C/EPBβ；旧称NF-IL6）、激活蛋白（AP）-1（Burger 2013）和CREB转录因子（Dendorfer等人，1994）的响应元件。人类IL-6的蛋白质形式是一种由184个氨基酸组成的糖蛋白，其分子量为21-28 kDa，具体取决于其糖基化程度。它具有由4个长α-螺旋组成的4螺旋束结构，这些螺旋以up-up-down-down的拓扑结构排列（Burger 2013）。